PMID 32625396 Re-evaluation of guar gum (E 412) as a food additive 기관 재평가 의견서 · EFSA Journal, 2017 일반 인구 수치 ADI 불필요·안전 우려 없음. 단 영유아 특수의료용도식품은 자료 부재로 평가 불가.
핵심요약
유럽식품안전청 식품첨가물패널의 구아검(E 412) 재평가 의견서입니다. 국제식품첨가물전문가위원회가 1970·1974·1975년에 '수치 미설정' 허용량을 부여했고 유럽 식품과학위원회가 1977년 승인했습니다. 구아검은 사실상 소화되지 않고 그대로 흡수되지 않으며 사람의 장내 세균이 상당히 발효시킵니다. 아만성·발암성 시험 최고 용량에서 이상반응이 없었고 유전독성 우려도 없었으며 성인의 경구 섭취는 잘 견뎠습니다. 결론은 수치 허용량 불필요, 일반 인구 안전 우려 없음입니다. 영유아용 식품에 대해서는 복부 불편감 발생을 모니터링하고 관찰되면 용량을 특정해 추가 평가 근거로 삼도록 권고했으며, 식품 분류 13.1.5.1과 13.1.5.2에 대해서는 적절한 연구가 없어 안전성을 적절히 평가할 수 없다고 밝혔습니다.
원문 초록 보기
The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of guar gum (E 412) as a food additive. In the EU, guar gum was evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1970, 1974 and 1975, who allocated an acceptable daily intake (ADI) 'not specified'. Guar gum has been also evaluated by the Scientific Committee for Food (SCF) in 1977 who endorsed the ADI 'not specified' allocated by JECFA. Following the conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010, the Panel considered that adequate exposure and toxicity data were available. Guar gum is practically undigested, not absorbed intact, but significantly fermented by enteric bacteria in humans. No adverse effects were reported in subchronic and carcinogenicity studies at the highest dose tested; no concern with respect to the genotoxicity. Oral intake of guar gum was well tolerated in adults. The Panel concluded that there is no need for a numerical ADI for guar gum (E 412), and there is no safety concern for the general population at the refined exposure assessment of guar gum (E 412) as a food additive. The Panel considered that for uses of guar gum in foods intended for infants and young children the occurrence of abdominal discomfort should be monitored and if this effect is observed doses should be identified as a basis for further risk assessment. The Panel considered that no adequate specific studies addressing the safety of use of guar gum (E 412) in food categories 13.1.5.1 and 13.1.5.2 were available. Therefore, the Panel concluded that the available data do not allow an adequate assessment of the safety of guar gum (E 412) in infants and young children consuming these foods for special medical purposes. ※ 파이프라인이 API로 수집·저장한 초록 원문 그대로. 한국어 핵심요약은 이 텍스트만을 근거로 작성됩니다.